• B cell receptor ligation induces display of V-region peptides on MHC class II molecules to T cells 

      Huszthy, Peter Csaba; Gopalakrishnan, Ramakrishna Prabhu; Jacobsen, Johanne Tracey; Haabeth, Ole Audun; Løset, Geir Åge; Braathen, Ranveig; Schenck, Karl; Tveita, Anders Aune; Munthe, Ludvig Andre; Bogen, Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-03)
      The B cell receptors (BCRs) for antigen express variable (V) regions that are enormously diverse, thus serving as markers on individual B cells. V region-derived idiotypic (Id) peptides can be displayed as pId:MHCII complexes on B cells for recognition by CD4<sup>+</sup> T cells. It is not known if naive B cells spontaneously display pId:MHCII in vivo or if BCR ligation is required for expression, ...
    • Immune complexes, innate immunity, and NETosis in ChAdOx1 vaccine-induced thrombocytopenia 

      Holm, Sverre; Kared, Hassen; Michelsen, Annika Elisabet; Kong, Xiang Yi; Dahl, Tuva Børresdatter; Schultz, Nina Haagenrud; Nyman, Tuula Anneli; Fladeby, Cathrine; Seljeflot, Ingebjørg; Ueland, Thor; Stensland, Maria; Mjaaland, Siri; Goll, Guro Løvik; Nissen-Meyer, Lise Sofie Haug; Aukrust, Pål; Skagen, Karolina Ryeng; Gregersen, Ida; Skjelland, Mona; Holme, Pål Andre; Munthe, Ludvig Andre; Halvorsen, Bente (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-18)
      Aims - We recently reported five cases of vaccine-induced immune thrombotic thrombocytopenia (VITT) 7–10 days after receiving the first dose of the ChAdOx1 nCoV-19 adenoviral vector vaccine against corona virus disease 2019 (COVID-19). We aimed to investigate the pathogenic immunological responses operating in these patients.<p> <p>Methods and results - We assessed circulating inflammatory markers ...
    • A national intercalated medical student research program–student perceptions, satisfaction, and factors associated with pursuing a PhD 

      Sandvei, Marie Søfteland; Jacobsen, Geir Wenberg; Stien, Marianne Heldal; Ræder, Helge; Munthe, Ludvig Andre; Skogen, Vegard (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-07)
      Background - To counteract a decreasing number of physician-scientists, a national intercalated Medical Student Research Programme (MSRP) was launched in Norway in 2002. We aimed to assess whether the students’ favourable perceptions and satisfaction with the program had prevailed since the inception in 2002 and until 2015, and to identify factors associated with pursuing a PhD.<p> <p>Methods - ...
    • Springboard to an academic career—A national medical student research program 

      Jacobsen, Geir Wenberg; Ræder, Helge; Stien, Marianne Heldal; Munthe, Ludvig Andre; Skogen, Vegard (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-30)
      Over the last decades there has been a decline in the recruitment of medical students into academia in all medical fields. Concurrently, medical research has increasingly included other disciplines in multidisciplinary convergence, introducing an unmet recruitment gap and requirement for medical researchers. To counteract the trend and recruit students to academic medicine, a national intercalated ...